Biochemical and structural characterization of <i>Haemophilus influenzae</i> nitroreductase in metabolizing nitroimidazoles-Reference-Cited by-同舟云学术

Biochemical and structural characterization of Haemophilus influenzae nitroreductase in metabolizing nitroimidazoles

Published:2022 Issue:4 Volume:3 Page:436-446
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Liu Dake¹,Wanniarachchi Thisuri N.²,Jiang Guangde¹,Seabra Gustavo¹,Cao Shugeng³^ORCID,Bruner Steven D.²,Ding Yousong¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida, 32610, USA

2. Department of Chemistry, University of Florida, Gainesville, Florida, 32611, USA

3. Department of Pharmaceutical Sciences, University of Hawai'i at Hilo, Hilo, Hawaii, 96720, USA

Abstract

The nitroreductase of Haemophilus influenzae metabolizes clinically used nitroimidazoles, generates dimeric metabolites and anaerobically sensitizes an E. coli mutant to antibiotics. We further uncover its biochemical and structural details.

Funder

National Institute of General Medical Sciences

University of Florida

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00238D

Reference52 articles.

1. Antibacterial drug discovery in the resistance era

2. Cyanobacterial Dihydroxyacid Dehydratases Are a Promising Growth Inhibition Target

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