Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1-Reference-Cited by-同舟云学术

Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1

Published:2015 Issue:27 Volume:13 Page:7487-7499
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hu Dawei¹²³⁴,Miyagi Namiki⁵⁶⁷⁴,Arai Yuki⁵⁶⁷⁴,Oguri Hiroaki⁵⁶⁷⁴,Miura Takeshi⁵⁸⁹¹⁰⁴,Nishinaka Toru⁵⁸⁹¹⁰⁴,Terada Tomoyuki⁵⁸⁹¹⁰⁴,Gouda Hiroaki¹¹¹²¹³⁴,El-Kabbani Ossama¹⁴¹⁵⁴,Xia Shuang¹⁶²³⁴,Toyooka Naoki¹²³⁴¹⁶,Hara Akira¹⁷¹⁸¹⁹⁴,Matsunaga Toshiyuki⁵⁶⁷⁴,Ikari Akira⁵⁶⁷⁴,Endo Satoshi⁵⁶⁷⁴^ORCID

Affiliation:

1. Graduate School of Innovative Life Science

2. University of Toyama

3. Toyama 930-8555

4. Japan

5. Laboratory of Biochemistry

6. Gifu Pharmaceutical University

7. Gifu 501-1196

8. Faculty of Pharmacy

9. Osaka Ohtani University

10. Osaka 584-8540

11. School of Pharmacy

12. Showa University

13. Tokyo 142-8555

14. Nagoya University Graduate School of Medicine

15. Nagoya 466-8550

16. Graduate School of Science and Technology

17. Faculty of Engineering

18. Gifu University

19. Gifu 501-1193

Abstract

Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase superfamily, reduces anthracycline anticancer drugs to their less potent anticancer C-13 hydroxy metabolites, which are linked with pathogenesis of cardiotoxicity, a side effect of the drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00847F

Reference49 articles.

1. Carbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short-chain Dehydrogenase/reductase Superfamily

2. Carbonyl Reductases: The Complex Relationships of Mammalian Carbonyl- and Quinone-Reducing Enzymes and Their Role in Physiology

3. Human Carbonyl Reductases

4. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

5. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

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