Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery
Author:
Affiliation:
1. Department of Physiology and Biomedical Engineering
2. Mayo Clinic
3. Rochester
4. USA
5. Department of Orthopedic Surgery
6. Department of Radiology
7. Division of Cardiovascular Medicine
8. Nebraska Medical Center
9. Omaha
Abstract
Strain-promoted alkyne–azide cycloaddition (SPAAC) click chemistry was applied for the rapid conjugation of nanoparticles, proteins, and siRNA-micelles to ultrasound microbubbles.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2019/PY/C8PY01721B
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4. Ultrasound-activated Agents Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor Growth and Improve Survival
5. Ultrasound‐Triggered Destruction of Folate‐Functionalized Mesoporous Silica Nanoparticle‐Loaded Microbubble for Targeted Tumor Therapy
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