Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery

Author:

Liu Xifeng12345ORCID,Gong Ping6234ORCID,Song Pengfei6234,Xie Feng7894,Miller II A. Lee5234,Chen Shigao6234,Lu Lichun12345

Affiliation:

1. Department of Physiology and Biomedical Engineering

2. Mayo Clinic

3. Rochester

4. USA

5. Department of Orthopedic Surgery

6. Department of Radiology

7. Division of Cardiovascular Medicine

8. Nebraska Medical Center

9. Omaha

Abstract

Strain-promoted alkyne–azide cycloaddition (SPAAC) click chemistry was applied for the rapid conjugation of nanoparticles, proteins, and siRNA-micelles to ultrasound microbubbles.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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