Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones-Reference-Cited by-同舟云学术

Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones

Published:2017 Issue:49 Volume:53 Page:6641-6644
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kambale Digambar A.¹²³⁴⁵,Thorat Sagar S.¹²³⁴⁵,Pratapure Madhukar S.¹²³⁴⁵,Gonnade Rajesh G.⁵⁶⁴⁷²^ORCID,Kontham Ravindar¹²³⁴⁵^ORCID

Affiliation:

1. Organic Chemistry Division

2. CSIR-National Chemical Laboratory

3. Pune-411008

4. India

5. Academy of Scientific and Innovative Research (AcSIR)

6. New Delhi

7. Centre for Materials Characterization

Abstract

A simple protocol for the synthesis of diverse unsaturated γ-spiroketal-γ-lactones has been developed by employing a Bi(OTf)₃ catalyzed cascade annulation of alkynols with α-ketoesters via a dual (π and σ) activation process.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC03668J

Reference64 articles.

1. Nonanomeric Spiroketals in Natural Products: Structures, Sources, and Synthetic Strategies

2. Strategies in Spiroketal Synthesis Revisited: Recent Applications and Advances

3. Chemistry of spiroketals

4. Advances in the Total Synthesis of Biologically Important Marine Macrolides

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