Peptide-mediated targeted delivery of SOX9 nanoparticles into astrocytes ameliorates ischemic brain injury

Author:

Shin Hyo Jung123ORCID,Choi Seung Gyu12ORCID,Qu Fengrui4ORCID,Yi Min-Hee5ORCID,Lee Choong-Hyun6,Kim Sang Ryong7,Kim Hyeong-Geug8,Beom Jaewon9ORCID,Yi Yoonyoung10,Kim Do Kyung11,Joe Eun-Hye12,Song Hee-Jung13ORCID,Kim Yonghyun14ORCID,Kim Dong Woon123ORCID

Affiliation:

1. Department of Medical Science, Chungnam National University, Daejeon 35015, Korea

2. Department of Anatomy and Cell Biology, Chungnam National University, Daejeon 35015, Korea

3. Brain Research Institute, Chungnam National University, Daejeon 35015, Korea

4. Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487, USA

5. Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA

6. Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Korea

7. School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, Korea

8. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

9. Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea

10. Department of Pediatrics, College of Medicine, Hallym University and Gangdong Sacred Heart Hospital, Seoul 05355, Korea

11. Department of Anatomy, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea

12. Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Suwon, Kyunggi-do, 16499, Korea

13. Department of Neurology, Chungnam National University and Sejong Hospital, Sejong 30099, Korea

14. Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487, USA

Abstract

We describes the development of a poly-lactic-coglycolic acid (PLGA) nanoparticle-based system for conjugation of targeting peptides to PLGA nanoparticles and delivery of the therapeutic gene SOX9 to damaged astrocytes in a mouse stroke model.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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