Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients-Reference-Cited by-同舟云学术

Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients

Published:2015 Issue:6 Volume:4 Page:1479-1487
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

AlGhamdi S.¹²³⁴⁵,Leoncikas V.¹²³⁴⁵,Plant K. E.¹²³⁴⁵,Plant N. J.¹²³⁴⁵

Affiliation:

1. Department of Biochemistry and Physiology

2. Faculty of Health and Medical Sciences

3. University of Surrey

4. Guildford

5. UK

Abstract

Doxorubicin and lipid-loading (steatosis) interact synergistically in Huh7 hepatoma cells. This results in enhanced cytotoxicity and pro-inflammatory ROS accumulation.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00173K

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