Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity-Reference-Cited by-同舟云学术

Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity

Published:2017 Issue:17 Volume:53 Page:2618-2621
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Hangxiang¹²³⁴⁵^ORCID,Wu Jiaping¹²³⁴⁵,Xu Li¹²³⁴⁵,Xie Ke¹²³⁴⁵,Chen Chao⁶⁷⁸⁹,Dong Yuehan¹⁰¹¹⁵⁹

Affiliation:

1. The First Affiliated Hospital

2. School of Medicine; Key Laboratory of Combined Multi-Organ Transplantation

3. Ministry of Public Health; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

4. Zhejiang University

5. Hangzhou

6. College of Life Sciences

7. Huzhou University

8. Huzhou

9. P. R. China

10. Department of Applied Engineering

11. Zhejiang Economic and Trade Polytechnic

Abstract

We present novel HSA-based nanoassemblies for the formulation of highly potent cytotoxic therapeutic drugs such as maytansinoid DM1.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC08978J

Reference36 articles.

1. Antimitotic Activity of the Potent Tumor Inhibitor Maytansine

2. Recent Developments in the Maytansinoid Antitumor Agents

3. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

4. Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

5. Arming antibodies: prospects and challenges for immunoconjugates

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