Considering both small and large scale motions of vascular endothelial growth factor (VEGF) is crucial for reliably predicting its binding affinities to DNA aptamers
Author:
Affiliation:
1. Department of Chemistry
2. Pohang University of Science and Technology (POSTECH)
3. Pohang 37673
4. Korea
5. Korea Advanced Institute of Science and Technology (KAIST)
6. Daejeon 34141
Abstract
Considering both small and large scale motions of VEGF is crucial to predict its relative binding affinities to DNA aptamer variants with docking.
Funder
National Research Foundation of Korea
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10106K
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1. An Ensemble Docking Approach for Analyzing and Designing Aptamer Heterodimers Targeting VEGF165;International Journal of Molecular Sciences;2024-04-05
2. Molecular mechanism of binding between a therapeutic RNA aptamer and its protein target VEGF: A molecular dynamics study;Journal of Computational Chemistry;2023-01-10
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