Alkyne-tagged imidazolium-based membrane cholesterol analogs for Raman imaging applications

Author:

Schultz Constanze1ORCID,Wegner Tristan2ORCID,Heusel Corinna2,Gallagher Tim2,Zheng Yanjun3,Werner Markus4,Wegner Seraphine V.3ORCID,Meyer-Zedler Tobias15ORCID,Werz Oliver4,Schmitt Michael5ORCID,Popp Juergen15ORCID,Glorius Frank2ORCID

Affiliation:

1. Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI), Albert-Einstein-Str. 9, 07745 Jena, Germany

2. University of Münster, Institute of Organic Chemistry, Corrensstraße 40, 48149 Münster, Germany

3. University of Münster, Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstraße 15, 48149 Münster, Germany

4. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany

5. Institute of Physical Chemistry (IPC) and Abbe Center of Photonics (ACP), Member of the Leibniz Center for Photonics in Infection Research (LPI), Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany

Abstract

Headgroup-labelled alkyne-tagged cholesterol mimetics with imidazolium cores were designed and probed for their use as Raman probes in mammalian cells. The analogs feature high membrane integration and tunability of their vibrational signature.

Funder

Leibniz-Gemeinschaft

Deutsche Forschungsgemeinschaft

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

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