Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging

Author:

Ding Yanfeng12,Li Zhimin23,Hu Wenwen4,Feng Xianjing5,Chen Ying4,Yan Guohua26,Wang Yonglin2,Zhu Bo12,Yao Wei12,Zheng Li12ORCID,He Maolin3,Gao Ming12ORCID,Zhao Jinmin1267ORCID

Affiliation:

1. Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

2. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

3. Division of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

4. Life Sciences Institute, Guangxi Medical University, Nanning, 530021, China

5. Pharmaceutical College, Guangxi Medical University, Nanning, 530021, China

6. Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

7. Guangxi Key Liboratory of Regenerative Medicine, Guangxi Medical University, Nanning, 530021, China

Abstract

Reacting with reactive oxygen species (ROS) by C–H hydrogen abstraction, carbazate modified sephadex served as potent ROS scavengers, with excellent antioxidant and anti-inflammatory abilities, finally suppressing the progress of osteoarthritis.

Funder

Natural Science Foundation of Guangxi Province

Youth Science Foundation of Guangxi Medical University

National Natural Science Foundation of China

Specific Research Project of Guangxi for Research Bases and Talents

Science and Technology Major Project of Guangxi

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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