CLPFFD–PEG functionalized NIR-absorbing hollow gold nanospheres and gold nanorods inhibit β-amyloid aggregation

Author:

Ruff J.1234,Hassan N.56789ORCID,Morales-Zavala F.101112138ORCID,Steitz J.141534ORCID,Araya E.16171889ORCID,Kogan M. J.101112138ORCID,Simon U.1234ORCID

Affiliation:

1. Institute of Inorganic Chemistry

2. RWTH Aachen University

3. Aachen

4. Germany

5. Programa Institucional de Fomento a la Investigación

6. Desarrollo e Innovación

7. Universidad Tecnológica Metropolitana

8. Santiago

9. Chile

10. Laboratorio de Nanobiotecnologia

11. Departamento de Quimica Farmacologica y Toxicologica

12. Facultad de Ciencias Quimicas y Farmaceuticas

13. Universidad de Chile and Advanced Center for Chronic Diseases (ACCDiS)

14. Institute for Laboratory Animal Science

15. University Hospital of the RWTH Aachen University

16. Departamento de Ciencias Químicas

17. Facultad de Ciencias Exactas

18. Universidad Andres Bello

Abstract

Gold nanoparticles with specific optical properties in combination with the CLPFFD peptide that exhibits selectivity for β-amyloid (Aβ) aggregates are promising photothermal absorbers for application in Alzheimer's disease therapy.

Funder

European Regional Development Fund

Deutsche Forschungsgemeinschaft

Fondo Nacional de Desarrollo Científico y Tecnológico

Comisión Nacional de Investigación Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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