Proanthocyanidins isolated from the leaves of Photinia × fraseri block the cell cycle and induce apoptosis by inhibiting tyrosinase activity in melanoma cells
Author:
Affiliation:
1. School of Life Science and Engineering
2. Henan University of Urban Construction
3. Pingdingshan
4. China
5. College of Life Science
6. Yangtze University
7. Jingzhou
8. Forestry College
Abstract
Proanthocyanidins isolated from the leaves of P. × fraseri can affect melanin production by downregulating MITF expression and inhibiting tyrosinase and TRP-1 activities, leading to cell cycle arrest and apoptosis of melanoma cells.
Funder
Hubei Provincial Department of Education
Key Scientific Research Project of Colleges and Universities in Henan Province
Publisher
Royal Society of Chemistry (RSC)
Subject
General Medicine,Food Science
Link
http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO00134E
Reference52 articles.
1. Mechanistic Aspects of the Control of Tyrosinase Activity
2. Tyrosinase inhibitors from marine algae
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4. An improved and combined reverse transcription-polymerase chain reaction assay for reliable detection of metastatic melanoma cells in peripheral blood
5. Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma
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