Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium-Reference-Cited by-同舟云学术

Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium

Published:2017 Issue:41 Volume:15 Page:8827-8835
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Serrano-Hervás Eila¹²³⁴^ORCID,Garcia-Borràs Marc⁵⁶⁷⁷⁸^ORCID,Osuna Sílvia¹²³⁴^ORCID

Affiliation:

1. Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química

2. Universitat de Girona

3. 17003 Girona

4. Spain

5. Department of Chemistry and Biochemistry

6. University of California

7. Los Angeles

8. USA

Abstract

Epoxide hydrolase (EH) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. In this work, the Bacillus megaterium epoxide hydrolase (BmEH)-mediated hydrolysis of racemic styrene oxide (rac-SO) and its para-nitro styrene oxide (rac-p-NSO) derivative are computationally investigated using density functional theory (DFT).

Funder

H2020 European Research Council

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01847A

Reference54 articles.

1. Synthetic applications of epoxide hydrolases

2. Biocatalytic conversion of epoxides