Unusual mode of protein binding by a cytotoxic π-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand-Reference-Cited by-同舟云学术

Unusual mode of protein binding by a cytotoxic π-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand

Published:2016 Issue:31 Volume:45 Page:12283-12287
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Hildebrandt Jana¹²³,Görls Helmar¹²³,Häfner Norman⁴⁵³,Ferraro Giarita⁶⁷⁸,Dürst Matthias⁴⁵³,Runnebaum Ingo B.⁴⁵³,Weigand Wolfgang¹²³,Merlino Antonello⁶⁷⁸⁹¹⁰

Affiliation:

1. Department of Inorganic and Analytical Chemistry

2. University of Jena

3. Germany

4. Department of Gynecology

5. Jena University Hospital - Friedrich-Schiller-University Jena

6. Department of Chemical Sciences

7. University of Naples Federico II

8. Italy

9. Institute of Biostructures and Bioimages

10. Naples

Abstract

A new π-arene Ru(ii) piano-stool compound, showing significant cytotoxic activityin vitro, was synthesized. The X-ray structure of this compound and that of its complex with RNase A were determined.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT02380K

Reference42 articles.

1. Direct Cellular Responses to Platinum-Induced DNA Damage

2. Cisplatin – Chemistry and Biochemistry of a Leading Anticancer Drug, ed. B. Lippert, VCHA, Zürich, Wiley-VCH, Weinheim, 1999, pp. 1–563

3. Cisplatin in cancer therapy: Molecular mechanisms of action

4. Metal-based antitumour drugs in the post-genomic era: what comes next?

5. Bioorganometallic chemistry—from teaching paradigms to medicinal applications

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