Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives

Author:

Ruddarraju Radhakrishnam Raju123,Murugulla Adharvana Chari123,Kotla Ravindar123,Tirumalasetty Muni Chandra Babu45678,Wudayagiri Rajendra45678,Donthabakthuni Shobha123,Maroju Ravichandar9103

Affiliation:

1. Dr.MACS Bio-Pharma Pvt. Ltd

2. Patancheru

3. India

4. Bioinformatics Center

5. Division of Molecular Biology

6. Department of Zoology

7. Sri Venkateswara University

8. Tirupati-517 502

9. Mahatma Gandhi Institute of Technology

10. Hyderabad-500 075

Abstract

A new series of theophylline analogues containing 1,2,3-triazoles with different amide groups (22–41) has been designed and synthesized, and their biological activities have been evaluated as potential anticancer agents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Reference31 articles.

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5. Cancer Survival in England: Patients Diagnosed (2007–2011) and Followed up to 2012, Office for National Statistics, 29 October 2013, Retrieved, 29 June 2014

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