A chiral phosphazane reagent strategy for the determination of enantiomeric excess of amines-Reference-Cited by-同舟云学术

A chiral phosphazane reagent strategy for the determination of enantiomeric excess of amines

Published:2022 Issue:18 Volume:13 Page:5398-5412
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Peel Andrew J.¹,Terzopoulos Alexandros¹,Jethwa Rajesh B.¹^ORCID,Choudhury Dipanjana¹,Niu Hao-Che¹,Bond Andrew D.¹^ORCID,Slaughter Jonathan¹²^ORCID,Wright Dominic S.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, Cambridge University, Lensfield Road, Cambridge, CB2 1EW, UK

2. The Faraday Institution Quad One, Harwell Science and Innovation Campus, Didcot, UK

Abstract

The simple inorganic cyclodiphosph(iii)azane chiral derivatisation agent ClP(μ-tBuN)2POBorn (Born = endo-(1S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl) is shown to be effective in the measurement of ee’s of chiral amines using 31P NMR spectroscopy.

Funder

Leverhulme Trust

Engineering and Physical Sciences Research Council

Faraday Institution

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01692C

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