Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates

Author:

Rajasekar Shravanthi1ORCID,Lin Dawn S. Y.1,Zhang Feng2,Sotra Alexander12,Boshart Alex34,Clotet-Freixas Sergi34,Liu Amy5,Hirota Jeremy A.267ORCID,Ogawa Shinichiro8910ORCID,Konvalinka Ana3491112ORCID,Zhang Boyang12

Affiliation:

1. Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada

2. School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada

3. Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

4. Renal Transplant Program, Soham and Shaila Ajmera Family Transplant Centre, University Health Network, Toronto, Ontario, Canada

5. Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada

6. Department of Medicine, Division of Respirology, McMaster University, 1200 Main St W, Hamilton, ON, L8N 3Z5, Canada

7. Firestone Institute for Respiratory Health, St. Joseph's Hospital, Hamilton, ON, L8N 4A6, Canada

8. McEwen Stem Cell Institute, University Health Network, MaRS Center, 101 College St, Toronto, Ontario, M5G 1L7, Canada

9. Department of Laboratory Medicine and Pathobiology, University of Toronto, MaRS Center, 101 College St, Toronto, Ontario, M5G 1L7 Canada

10. Liver Transplant Program, Soham and Shaila Ajmera Family Transplant Centre, University Health Network, Toronto, Ontario, Canada

11. Department of Medicine, Division of Nephrology, University Health Network, Toronto, Ontario, Canada

12. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

Abstract

We developed a subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in high-throughput multi-well plate formats.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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