Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics-Reference-Cited by-同舟云学术

Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics

Published:2021 Issue:41 Volume:19 Page:8940-8946
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

De Bidhan Chandra¹²,Zhang Wenjun¹²³^ORCID,Zhang Guangtao¹³,Liu Zhiwen¹,Tan Bin¹³,Zhang Qingbo¹³,Zhang Liping¹³,Zhang Haibo¹³^ORCID,Zhu Yiguang¹²³,Zhang Changsheng¹²³^ORCID

Affiliation:

1. Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China

2. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China

3. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), 1119 Haibin Rd., Nansha District, Guangzhou 511458, China

Abstract

Linearized berninamycin analogues were generated by heterologous expression of the ber biosynthetic gene cluster from deep-sea derived Streptomyces sp. SCSIO 11878 in S. albus, but neither in S. lividans nor in S. coelicolor.

Funder

National Natural Science Foundation of China

National Science and Technology Major Project

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01759D

Reference50 articles.

1. Refactoring biosynthetic gene clusters for heterologous production of microbial natural products