A fluorescence and photoactivity dual-activatable prodrug with self-synergistic magnification of the anticancer effect-Reference-Cited by-同舟云学术

A fluorescence and photoactivity dual-activatable prodrug with self-synergistic magnification of the anticancer effect

Published:2019 Issue:7 Volume:3 Page:1349-1356
ISSN:2052-1537
Container-title:Materials Chemistry Frontiers
language:en
Short-container-title:Mater. Chem. Front.

Author:

Li Jun¹²³⁴⁵,Ni Xiang¹²³⁴⁵,Zhang Jingtian¹²³⁴⁵,Liang Yong⁶⁷⁸⁹⁵,Gao Zhiyuan¹²³⁴⁵,Zhang Xiaoyan¹²³⁴⁵,Zheng Donghui⁶⁷⁸⁹⁵,Ding Dan¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Bioactive Materials Ministry of Education

2. College of Life Sciences, and State Key Laboratory of Medicinal Chemical Biology

3. Nankai University

4. Tianjin 300071

5. China

6. Department of Nephrology

7. Clinical Laboratory

8. Huai'an Hospital Affiliated to Xuzhou Medical University and Huai'an Second Hospital

9. Huai'an 223002

Abstract

A hydroxycamptothecin prodrug is developed, which can self-report the drug distribution and achieve self-synergistic anticancer efficacy through oxidation therapy.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

South China University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QM/C9QM00081J

Reference59 articles.

1. Nanotechnology for Multimodal Synergistic Cancer Therapy

2. Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

3. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

4. Nucleopeptide Assemblies Selectively Sequester ATP in Cancer Cells to Increase the Efficacy of Doxorubicin

5. RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

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