Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug-Reference-Cited by-同舟云学术

Mechanistic study of the solubilization effect of basic amino acids on a poorly water-soluble drug

Published:2022 Issue:30 Volume:12 Page:19040-19053
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alsalhi Mohammed Suleiman¹^ORCID,Royall Paul G.¹^ORCID,Chan Ka Lung Andrew¹

Affiliation:

1. Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK

Abstract

Amino acids have shown promising abilities to form complexes with poorly water-soluble drugs and improve their physicochemical properties for a better dissolution profile through molecular interactions.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA02870K

Reference66 articles.

1. Biopharmaceutics: From Fundamentals to Industrial Practice , ed. H. Batchelor , Wiley , Chichester , 1st edn, 2021 , p. 320

2. Drug Solubility: Importance and Enhancement Techniques

3. Strategies to Address Low Drug Solubility in Discovery and Development

4. Salt formation to improve drug solubility

5. Preparation and characterization of amorphous ciprofloxacin-amino acid salts

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