A study of ad-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9-Reference-Cited by-同舟云学术

A study of ad-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

Published:2015 Issue:2 Volume:6 Page:277-282
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Bianchini Francesca¹²³⁴,Calugi Chiara²⁵⁶⁴,Ruzzolini Jessica¹²³⁴,Menchi Gloria²⁵⁶⁴,Calorini Lido¹²³⁴,Guarna Antonio²⁵⁶⁴,Trabocchi Andrea²⁵⁶⁴

Affiliation:

1. Department of Clinical and Experimental Biomedical Science “Mario Serio”

2. University of Florence

3. 50134 Florence

4. Italy

5. Department of Chemistry “Ugo Schiff”

6. Florence

Abstract

Ad-proline peptidomimetic targeting MMP-2 and MMP-9 was identified from a pool of compounds following enzyme inhibition kinetics and Matrigel sponge assays, showing the capacity of blocking capillary network formationin vivo.

Funder

Ente Cassa di Risparmio di Firenze

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00287C

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