Synthesis and structure–activity relationships of pirfenidone derivatives as anti-fibrosis agents <i>in vitro</i>-Reference-Cited by-同舟云学术

Synthesis and structure–activity relationships of pirfenidone derivatives as anti-fibrosis agents in vitro

Published:2022 Issue:5 Volume:13 Page:610-621
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Shi Xiufang¹²³,Yu Zhenqiang¹²³,Zhu Chaoran¹²³,Jiang Linlin¹²³,Geng Nanqi¹²³,Fan Xingting¹²³,Guan Zhanghui¹²³,Lu Xiang¹²³^ORCID

Affiliation:

1. Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Henan Province, China

2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, China

3. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China

Abstract

Total 18 PFD derivatives with the amide group replacing 5-methyl were synthesized and evaluated. YZQ17 possessed considerable antifibrosis activity in vitro via TGF-β/Smad2/3 pathway and was regarded as a lead compound for further optimization.

Funder

National College Students Innovation and Entrepreneurship Training Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00403D

Reference26 articles.

1. Lung Fibrosis after COVID-19: Treatment Prospects

2. Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

3. Idiopathic Pulmonary Fibrosis

4. Incidence and Prevalence of Idiopathic Pulmonary Fibrosis

5. Idiopathic pulmonary fibrosis

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