Reactivity of copper–α-synuclein peptide complexes relevant to Parkinson's disease-Reference-Cited by-同舟云学术

Reactivity of copper–α-synuclein peptide complexes relevant to Parkinson's disease

Published:2015 Issue:7 Volume:7 Page:1091-1102
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Dell'Acqua Simone¹²³,Pirota Valentina¹²³,Anzani Cecilia¹²³,Rocco Michela M.¹²³,Nicolis Stefania¹²³,Valensin Daniela⁴⁵⁶⁷,Monzani Enrico¹²³,Casella Luigi¹²³

Affiliation:

1. Dipartimento di Chimica

2. Università di Pavia

3. 27100 Pavia, Italy

4. Dipartimento di Biotecnologie

5. Chimica e Farmacia

6. Università di Siena

7. 53100 Siena, Italy

Abstract

Competitive oxidative experiments with exogenous catechols show that copper–α-synuclein complexes can significantly promote endogenous peptide sulfoxidation at Met residues, which is relevant for protein oxidative damage.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C4MT00345D

Reference51 articles.

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3. α-Synuclein and Dopamine Metabolism

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5. Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

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