Rational design, synthesis, and 2D-QSAR study of anti-oncological alkaloids against hepatoma and cervical carcinoma-Reference-Cited by-同舟云学术

Rational design, synthesis, and 2D-QSAR study of anti-oncological alkaloids against hepatoma and cervical carcinoma

Published:2015 Issue:36 Volume:5 Page:28554-28569
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Girgis Adel S.¹²³⁴,Panda Siva S.⁵⁶⁷⁸⁹,Aziz Marian N.¹²³⁴,Steel Peter J.¹⁰¹¹¹²¹³,Dennis Hall C.⁵⁶⁷⁸⁹,Katritzky Alan R.⁵⁶⁷⁸⁹

Affiliation:

1. Pesticide Chemistry Department

2. National Research Centre

3. Cairo 12622

4. Egypt

5. Center for Heterocyclic Compounds

6. Department of Chemistry

7. University of Florida

8. Gainesville

9. USA

10. Chemistry Department

11. University of Canterbury

12. Christchurch

13. New Zealand

Abstract

A series of novel substituted dispiro-oxindole were synthesized and screened for anti-cancer properties. The anti-cancer data were validated by QSAR studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA16663A

Reference60 articles.

1. 15 million new cancer cases per year by 2020, says WHO

2. A review of global cancer burden: Trends, challenges, strategies, and a role for surgeons

3. Novel merosesquiterpene exerts a potent antitumor activity against breast cancer cells in vitro and in vivo

4. Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins

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