N,N′,N′′-Trisubstituted guanidine derivatives as DNA-intercalators: synthesis, crystal structures and biophysical investigations-Reference-Cited by-同舟云学术

N,N′,N′′-Trisubstituted guanidine derivatives as DNA-intercalators: synthesis, crystal structures and biophysical investigations

Published:2023 Issue:30 Volume:47 Page:14185-14194
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Durga Priyadharshini R.¹,Sathishkumar P. N.²,Bensingh M.²,Bhuvanesh N.³,Vennila K. N.¹^ORCID,Karvembu R.²^ORCID,Elango Kuppanagounder P.¹^ORCID

Affiliation:

1. Department of Chemistry, Gandhigram Rural Institute – Deemed to be University, Gandhigram 624302, India

2. Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, India

3. Department of Chemistry, Texas A & M University, College Station, TX 77842, USA

Abstract

Biophysical and metadynamics simulation studies indicated partial intercalation of one of the phenyl rings of N,N′,N′′-trisubstituted guanidine derivatives between the base pairs of DNA.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01327H

Reference50 articles.

1. Drug–DNA interactions and their study by UV–Visible, fluorescence spectroscopies and cyclic voltametry

2. The chemistry and biology of organic guanidine derivatives

3. Biological activities of guanidine compounds

4. Antimicrobial drugs bearing guanidine moieties: A review

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