Enantioselective decarboxylative Mannich reaction of β-keto acids with C-alkynyl N-Boc N,O-acetals: access to chiral β-keto propargylamines-Reference-Cited by-同舟云学术

Enantioselective decarboxylative Mannich reaction of β-keto acids with C-alkynyl N-Boc N,O-acetals: access to chiral β-keto propargylamines

Author:

Zhang Cong-Cong¹,Chen Li-Jun¹,Shen Bao-Chun¹,Xie Hui-Ding¹,Li Wei¹,Sun Zhong-Wen¹²^ORCID

Affiliation:

1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China

2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Yunnan University, Kunming, 650091, China

Abstract

The first asymmetric Mannich reaction of C-alkynyl N-Boc N,O-acetals with β-ketoacids has been developed to access chiral β-keto propargylamines.

Funder

Yunnan Provincial Science and Technology Department

Kunming Medical University

Southwest Forestry University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference85 articles.

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