Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

Author:

Findlay Michael T.1ORCID,Hogg Ashley S.1,Douglas James J.2ORCID,Larrosa Igor1ORCID

Affiliation:

1. Department of Chemistry, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK

2. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

Abstract

A ruthenium-catalysed C–H arylation procedure that utilises a range of green solvents in place of the undesirable solvent NMP is presented. Examples of fast reaction time, low catalyst loading and large-scale reactivity are also shown.

Funder

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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