Towards understanding non-equivalence of α and β subunits within human hemoglobin in conformational relaxation and molecular oxygen rebinding-Reference-Cited by-同舟云学术

Towards understanding non-equivalence of α and β subunits within human hemoglobin in conformational relaxation and molecular oxygen rebinding

Published:2021 Issue:20 Volume:12 Page:7033-7047
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lepeshkevich Sergei V.¹²³⁴^ORCID,Sazanovich Igor V.⁵⁶⁷⁸^ORCID,Parkhats Marina V.¹²³⁴,Gilevich Syargey N.⁹²¹⁰⁴,Dzhagarov Boris M.¹²³⁴

Affiliation:

1. B. I. Stepanov Institute of Physics

2. National Academy of Sciences of Belarus

3. Minsk 220072

4. Belarus

5. Central Laser Facility

6. Research Complex at Harwell

7. STFC Rutherford Appleton Laboratory

8. UK

9. Institute of Bioorganic Chemistry

10. Minsk 220141

Abstract

O₂ rebinding and conformational relaxation following O₂ photodissociation were studied on picosecond to millisecond time scale in the α and β subunits within human hemoglobin in the quaternary R-like structure.

Funder

Belarusian Republican Foundation for Fundamental Research

Science and Technology Facilities Council

National Academy of Sciences of Belarus

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00712B

Reference63 articles.

1. Experimental basis for a new allosteric model for multisubunit proteins

2. Photosensitivity of Hæm Compounds

3. The effects of E7 and E11 mutations on the kinetics of ligand binding to R state human hemoglobin

4. Kinetic investigations of the quaternary enhancement effect and alpha/beta differences in binding the last oxygen to hemoglobin tetramers and dimers.

5. Rate Constants for O2 and CO Binding to the α and β Subunits within the R and T States of Human Hemoglobin

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ultrafast Spectroscopy at the Central Laser Facility;Johnson Matthey Technology Review;2024-10-01

2. Molecular Oxygen Migration in Isolated β-Chains of Human Hemoglobin as Revealed by Molecular Dynamics Simulations and Laser Kinetic Spectroscopy;Journal of Applied Spectroscopy;2023-06-26

3. Bimolecular Recombination of Molecular Oxygen with Sol–Gel Encapsulated Hemoglobin in a Nonequilibrium T-Conformation;Journal of Applied Spectroscopy;2023-05

4. Kinetic mechanisms for O2 binding to myoglobins and hemoglobins;Molecular Aspects of Medicine;2022-04