Bioinspired immuno-radio-enhancers toward synergistic nanomedicine through radiation-induced abscopal effects and immunocheckpoint blockade therapies

Author:

Zhang Pengfei12,Chen Hu12,Chen Chuan1,Liu Xuan1,Cheng Hongwei34,Wu Yaming1,Wang Xiaoyong34,Liu Gang3ORCID,Zeng Yun1

Affiliation:

1. Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China

2. Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510000, China

3. State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen 361002, China

4. Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM) & Amoy Hopeful Biotechnology Co., Ltd, Xiamen 361027, China

Abstract

Membrane-cloaked manganese dioxide nanoparticles displaying anti-PD-L1 antibodies were developed as targeted immuno-radio-enhancers with a CpG immunomodulator encapsulated.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Guangdong Province

Program for New Century Excellent Talents in University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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