A membrane intercalating metal-free conjugated organic photosensitizer for bacterial photodynamic inactivation

Author:

Magni Arianna12ORCID,Mattiello Sara3ORCID,Beverina Luca3ORCID,Mattioli Giuseppe4ORCID,Moschetta Matteo2,Zucchi Anita3,Paternò Giuseppe Maria12ORCID,Lanzani Guglielmo12ORCID

Affiliation:

1. Department of Physics, Politecnico di Milano, 20133 Milan, Italy

2. Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, 20133 Milan, Italy

3. Department of Materials Science, University of Milano-Bicocca, 20125 Milan, Italy

4. CNR – Istituto di Struttura della Materia, I-00015 Monterotondo Scalo, Italy

Abstract

The molecule BV-1 is designed to target the bacterial membrane and produce reactive oxygen species at this location, leading to E. coli photo-inhibition at a relatively low minimum inhibition concentration.

Funder

Fondazione Cariplo

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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