Mechanistic study on C(sp2)–F bond activation by a Ni0(silyl)-ate complex: an outer-sphere pathway via Ni0-mediated nucleophilic aromatic substitution-Reference-Cited by-同舟云学术

Mechanistic study on C(sp²)–F bond activation by a Ni⁰(silyl)-ate complex: an outer-sphere pathway via Ni⁰-mediated nucleophilic aromatic substitution

Published:2024 Issue:14 Volume:11 Page:3913-3923
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

You Xiao-Xia¹,Wang Jian-Sen¹,Li Xiao-Xiao¹,Meng Ling-Qi²,Zhong Rong-Lin¹^ORCID,Su Zhong-Min¹³²

Affiliation:

1. Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun, 130021, P. R. China

2. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130012, China

3. State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130021, China

Abstract

DFT calculations and AIMD simulations reveal C(sp2)–F bond activation by a Ni0(silyl)-ate complex, involving an outer-sphere pathway via Ni0-mediated SNAr.

Funder

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00743C

Reference57 articles.

1. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

2. Chemical Aspects of Human and Environmental Overload with Fluorine

3. Current Contributions of Organofluorine Compounds to the Agrochemical Industry

4. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

5. Metabolic and Pharmaceutical Aspects of Fluorinated Compounds