Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC-Reference-Cited by-同舟云学术

Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC

Published:2018 Issue:4 Volume:17 Page:404-413
ISSN:1474-905X
Container-title:Photochemical & Photobiological Sciences
language:en
Short-container-title:Photochem. Photobiol. Sci.

Author:

Ikehata Hironobu¹²³⁴^ORCID,Mori Toshio⁵⁶⁷⁴,Douki Thierry⁸⁹¹⁰¹¹¹²^ORCID,Cadet Jean¹³¹⁴¹⁵,Yamamoto Masayuki¹²³⁴

Affiliation:

1. Department of Medical Biochemistry

2. Tohoku University Graduate School of Medicine

3. Sendai

4. Japan

5. Radioisotope Research Center

6. Nara Medical University School of Medicine

7. Kashihara

8. Université Grenoble Alpes

9. CEA

10. CNRS

11. INAC-SyMMES

12. 38000 Grenoble

13. University of Sherbrooke

14. Sherbrooke

15. Canada

Abstract

The quantification of UV photolesions with a calibrated ELISA and the mutation assay with transgenic mice revealed that the molecular genotoxicity of CPDs depends on UVR components and skin tissues.

Funder

Japan Society for the Promotion of Science

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/PP/C7PP00348J

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