Organocatalytic cascade reactions for multi-functionalized chiral cyclic ethers through vinylidene ortho-quinone methides

Author:

Jia Shiqi1,Chang Yu1,Tian Yuhong1,Mao Hui2,Qin Wenling1ORCID,Wang Pengfei1,Yan Hailong1ORCID

Affiliation:

1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China

2. College of Pharmacy, Jinhua Polytechnic, Jinhua, Zhejiang Province 321007, P. R. China

Abstract

An organocatalytic approach for installing various alcohols into the carbonyl of α,β-unsaturated ketones through VQM intermediates was achieved, followed by dearomatization to provide multi-functionalized chiral cyclic ethers via a cascade process.

Funder

Scientific Research Foundation for Returned Scholars of Ministry of Education

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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