Development of an actinium-225 radioimmunoconjugate for targeted alpha therapy against SARS-CoV-2-Reference-Cited by-同舟云学术

Development of an actinium-225 radioimmunoconjugate for targeted alpha therapy against SARS-CoV-2

Published:2022 Issue:33 Volume:46 Page:15795-15798
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Pallares Roger M.¹^ORCID,Flick Matthew¹,Shield Katherine M.¹²^ORCID,Bailey Tyler A.¹²,Velappan Nileena³,Lillo Antonietta M.³,Abergel Rebecca J.¹²^ORCID

Affiliation:

1. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA

2. Department of Nuclear Engineering, University of California, Berkeley, CA, 94720, USA

3. Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA

Abstract

Cytotoxicity was induced in cells mimicking SARS-CoV-2 infection by a 225Ac-radiolabeled antibody that targets the RBD2 of the spike protein.

Funder

Lawrence Berkeley National Laboratory

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ02617A

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