Acid-assisted self-assembly of pyrene-capped tyrosine ruptures lysosomes to induce cancer cell apoptosis-Reference-Cited by-同舟云学术

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Acid-assisted self-assembly of pyrene-capped tyrosine ruptures lysosomes to induce cancer cell apoptosis

Published:2024 Issue:23 Volume:14 Page:15840-15847
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Jing¹²,Song Jiaqi³,Shao Liang³,Zhang Xianpeng³^ORCID,Wang Ziyi¹²,Li Guanying³^ORCID,Wang Jiansheng¹²,Zhang Jia²

Affiliation:

1. The Second Clinical Medical School, Shaanxi University of Chinese Medicine, Xianyang Shaanxi, China

2. The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an Shaanxi, China

3. Department of Biophysics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an Shaanxi, China

Abstract

Acid-responsive assembly of pyrene-capped tyrosine induces lysosomal membrane permeabilization (LMP), triggering cancer apoptosis.

Funder

Xi'an Jiaotong University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01328J

Reference27 articles.

1. The role of lysosomes in cancer development and progression

2. Lysosomes as a therapeutic target

3. Lysosomes as a Target of Anticancer Therapy

4. Targeting lysosomes in human disease: from basic research to clinical applications

5. Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells

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