Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues-Reference-Cited by-同舟云学术

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Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

Published:2019 Issue:7 Volume:10 Page:1205-1211
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Aljahdali Alhanouf Z.¹²³^ORCID,Freedman Seth A.¹²³^ORCID,Scott Jana⁴⁵⁶³,Li Miaosheng⁴⁷³,O'Doherty George A.¹²³^ORCID

Affiliation:

1. Dept. of Chemistry and Chem. Bio

2. Northeastern Univ. Boston

3. USA

4. Dept. of Chemistry

5. Univ. of Minnesota

6. Minneapolis

7. West Virginia Univ. Morgantown

Abstract

The synthesis and biological evaluation of two phomopsolide natural products (D and E) and two analogues is presented.

Funder

Division of Chemistry

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00121B

Reference40 articles.

1. Metabolic products of Phomopsis oblonga. Part 2. Phomopsolide A and B, tiglic esters of two 6-substituted 5,6-dihydro-5-hydroxypyran-2-ones

2. New Phomopsolides from a Penicillium sp.

3. Total Synthesis of Natural (+)-Phomopsolide B, an Antifeedant against Elm Bark Beetle

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