One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

Author:

Lichman B. R.1234ORCID,Lamming E. D.5234,Pesnot T.5234,Smith J. M.1234,Hailes H. C.5234,Ward J. M.1234

Affiliation:

1. Department of Biochemical Engineering

2. University College London

3. London

4. UK

5. Department of Chemistry

Abstract

One-pot, one-substrate, triangular chemoenzymatic cascades featuring transaminase (TAm) and norcoclaurine synthase (NCS) enables the formation of (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids.

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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