Enantioselective synthesis of spirooxindole-pyran derivatives <i>via</i> a remote inverse-electron-demand Diels–Alder reaction of β,γ-unsaturated amides-Reference-Cited by-同舟云学术

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Enantioselective synthesis of spirooxindole-pyran derivatives via a remote inverse-electron-demand Diels–Alder reaction of β,γ-unsaturated amides

Published:2024 Issue:16 Volume:22 Page:3198-3203
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Yuzhen¹,Chen Jiajia²,Zhong Lin²,Zhang Yili²,Zhan Ruoting²,Huang Huicai²^ORCID,Xue Yongbo¹^ORCID

Affiliation:

1. School of Pharmaceutical Science (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, P.R. China

2. Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

Abstract

A remote inverse-electron-demand Diels–Alder reaction mediated by dienol intermediates of β,γ-unsaturated amides for the construction of spirooxindole-pyran derivatives.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00303A

Reference68 articles.

1. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

2. Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

3. Spirooxindoles: Promising scaffolds for anticancer agents

4. Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement

5. Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

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