Selenium-enriched soybean peptides pretreatment attenuates lung injury in mice induced by fine particulate matters (PM2.5) through inhibition of TLR4/NF-κB/IκBα signaling pathway and inflammasome generation

Author:

Zhang Jian1ORCID,Chen Xinwei1ORCID,Li He1ORCID,Liu Wanlu1,Liu Xinqi1,Song Yao2,Cong Xin3

Affiliation:

1. National Soybean Processing Industry Technology Innovation Center, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China

2. Handan Institute of Innovation, Peking University, Handan 056000, China

3. Enshi Se-Run Health Tech Development Co. Ltd., Enshi 445000, China

Abstract

Selenium-enriched soybean peptide attenuates lung injury induced by PM2.5, and the mechanism is mainly via inhibited TLR4/NF-κB/IκBα and NLRP3/ASC/caspase-1 protein expression.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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