Integrative chemoproteomics reveals anticancer mechanisms of silver(<scp>i</scp>) targeting the proteasome regulatory complex-Reference-Cited by-同舟云学术

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Integrative chemoproteomics reveals anticancer mechanisms of silver(i) targeting the proteasome regulatory complex

Published:2024 Issue:14 Volume:15 Page:5349-5359
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shao Xiaojian¹²^ORCID,Xing Fangrong¹²^ORCID,Zhang Yiwei¹²^ORCID,Lok Chun-Nam¹²^ORCID,Che Chi-Ming¹²^ORCID

Affiliation:

1. Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China

2. Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F., Building 17W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China

Abstract

A silver(i) complex AgTU exerts anticancer activities by releasing Ag+ ions that target and impair the 19S proteasomal complex, resulting in accumulation of ubiquitinated, misfolded proteins.

Funder

Innovation and Technology Commission - Hong Kong

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC04834A

Reference73 articles.

1. Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

2. Cisplatin binding to proteins: A structural perspective

3. Stimuli-Responsive Therapeutic Metallodrugs

4. Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles

5. Silver coordination compounds: A new horizon in medicine

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