Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process-Reference-Cited by-同舟云学术

Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process

Published:2014 Issue:68 Volume:50 Page:9657-9660
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Regenass Pierre¹²³⁴⁵,Margathe Jean-François¹²³⁴⁵,Mann André¹²³⁴⁵,Suffert Jean¹²³⁴⁵,Hibert Marcel¹²³⁴⁵,Girard Nicolas¹²³⁴⁵,Bonnet Dominique¹²³⁴⁵

Affiliation:

1. Laboratoire d'Innovation Thérapeutique

2. UMR7200 CNRS/Université de Strasbourg

3. Labex Médalis

4. Faculté de Pharmacie

5. 67412 Illkirch, France

Abstract

A short and diastereoselective synthesis of newly reported aza-diketopiperazine (aza-DKP) scaffolds starting from amino-acids was achieved using domino Rh(i)-catalyzed cyclohydrocarbonylation/addition.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC03660C

Reference27 articles.

1. Bioactive cyclic dipeptides

2. Diketopiperazines: biological activity and synthesis

3. Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles

4. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

5. Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis

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