Facile preparation of polycyclic halogen-substituted 1,2,3-triazoles by using intramolecular Huisgen cycloaddition-Reference-Cited by-同舟云学术

Facile preparation of polycyclic halogen-substituted 1,2,3-triazoles by using intramolecular Huisgen cycloaddition

Published:2023 Issue:48 Volume:21 Page:9610-9615
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kobayashi Kazuki¹,Kasakura Nozomi¹,Kikukawa Seiya¹,Matsumoto Shota²^ORCID,Karasawa Satoru²^ORCID,Hata Takeshi¹^ORCID

Affiliation:

1. Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-59 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan

2. Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida 194-8543, Japan

Abstract

1-(ω-Azidoalkyl)-2-(2,2-dihalovinyl)arenes afforded tricyclic 5-halo-1,2,3-triazoles via intramolecular Huisgen cycloaddition. Based on the remaining bromo groups, carbon elongation gave polycyclic compounds and a pentacyclic fluorescent compound.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01283B

Reference66 articles.

1. Comprehensive Heterocyclic Chemistry , ed. H. Wamhoff , A. R. Katritzky , C. W. Rees and E. F. V. Scriven , Elsevier Science , Oxford , 1996

2. Topics in Heterocyclic Chemistry 40 , ed. W. Dehan and V. A. Bakulev , Springer Cham Heidelberg , New York Dordrecht London , 2015

3. The growing impact of click chemistry on drug discovery

4. The growing applications of click chemistry

5. Click Chemistry: 1,2,3-Triazoles as Pharmacophores