Facile synthesis and antifungal evaluation of hypervalent organoantimony(iii) and organobismuth(iii) thioates with tridentate C,N,C-coordinating ligands

Author:

Wang Zixiu1,Huang Yan1,Deng Dandan1,Li Shan1,Yu Yimei1,Ye Yifei1,Chen Yi2,Lei Jian1ORCID

Affiliation:

1. Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Disease of the Ministry of Education, Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), College of Pharmacy, Gannan Medical University, Ganzhou 341000, PR China

2. School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, PR China

Abstract

A series of C,N,C-chelated organoantimony and -bismuth thioates were prepared as potential antifungal agents against C. albicans through an additive-free synthesis starting from thiols or a DTT-mediated cross-coupling with disulfides.

Funder

National Natural Science Foundation of China

Scientific Research Foundation of Hunan Provincial Education Department

Education Department of Jiangxi Province

Publisher

Royal Society of Chemistry (RSC)

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