Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions-Reference-Cited by-同舟云学术

Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions

Published:2019 Issue:45 Volume:10 Page:10481-10492
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Potowski Marco¹²³⁴,Losch Florian¹²³⁴,Wünnemann Elena¹²³⁴,Dahmen Janina K.¹²³⁴,Chines Silvia¹²³⁴,Brunschweiger Andreas¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology

2. TU Dortmund University

3. 44227 Dortmund

4. Germany

Abstract

DNA-encoded compound libraries are widely used in drug discovery. Screening of catalysts for compatibility with solid phase-coupled DNA sequences guided the selection of encoded reactions, exemplified by a Zn(II)-mediated aza-Diels–Alder reaction.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC04708E

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