Enzymatic synthesis of poly(ω-pentadecalactone-co-butylene-co-3,3′-dithiodipropionate) copolyesters and self-assembly of the PEGylated copolymer micelles as redox-responsive nanocarriers for doxorubicin delivery

Author:

Liu Bo1234,Zhang Xiaofang56734,Chen Ya56734,Yao Zhicheng1234,Yang Zhe56734,Gao Di56734,Jiang Qing56734,Liu Jie56734,Jiang Zhaozhong5891011

Affiliation:

1. Department of General Surgery

2. The Ling Nan Hospital of Sun Yat-sen University

3. Guangzhou

4. China

5. Department of Biomedical Engineering

6. School of Engineering

7. Sun Yat-sen University

8. Molecular Innovations Center

9. Yale University

10. West Haven

11. USA

Abstract

The PEG-polyester copolymers bearing disulfide groups were synthesized to serve as redox-responsive anticancer drug carriers with an enhanced efficacy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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