From basic physics to mechanisms of toxicity: the “liquid drop” approach applied to develop predictive classification models for toxicity of metal oxide nanoparticles

Author:

Sizochenko Natalia12345,Rasulev Bakhtiyor4567,Gajewicz Agnieszka891011,Kuz'min Victor123123,Puzyn Tomasz891011,Leszczynski Jerzy4567

Affiliation:

1. I. I. Mechnikov Odessa National University

2. Department of Chemistry

3. Odessa, Ukraine

4. Interdisciplinary Center for Nanotoxicity

5. Department of Chemistry and Biochemistry

6. Jackson State University

7. Jackson, USA

8. Laboratory of Environmental Chemometrics

9. Faculty of Chemistry

10. University of Gdansk

11. 80-308 Gdansk, Poland

12. A.V. Bogatsky Physical–Chemical Institute National Academy of Sciences of Ukraine

Abstract

HaCaTandE.colicells toxicity of MeOx nanoparticles were investigated. The new “liquid drop” model and SiRMS method were able to assess the factors responsible for toxicity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference53 articles.

1. J. A. Plant , N.Voulvoulis and K. V.Ragnarsdottir , Pollutants, Human Health and the Environment: A Risk Based, 2012

2. M. C. Garnett , in Nanonotoxicology: Characterization, dosing and health effects , ed. N. Monteiro-Riviere and C. Tran , New York , 2007

3. M. Horie and K.Fujita , in Advances in Molecular Toxicology , ed. J. C. Fishbein , Elsevier B.V. , Oxford , 2011 , vol. 5 , pp. 145–178

4. Metal‐based nanoparticles and their toxicity assessment

5. Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles

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