Synthesis and evaluation of a deltic guanidinium analogue of a cyclic RGD peptide-Reference-Cited by-同舟云学术

Synthesis and evaluation of a deltic guanidinium analogue of a cyclic RGD peptide

Published:2023 Issue:9 Volume:21 Page:1937-1941
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mishiro Kenji¹^ORCID,Ueno Takahiro²,Wakabayashi Hiroshi³,Fukui Masato²,Kinuya Seigo³,Ogawa Kazuma¹²^ORCID

Affiliation:

1. Institute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

2. Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

3. Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan

Abstract

The biological properties of deltic guanidinium derivatives such as target affinity, biodistribution, and metabolic stability have been studied for the first time, and the result suggested that deltic guanidinium could be a unique bioisostere of guanidinium.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Kanazawa University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00089C

Reference21 articles.

1. Macrosteres: The Deltic Guanidinium Ion

2. Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication