Toward once-monthly insulin therapy <i>via</i> synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation-Reference-Cited by-同舟云学术

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

Published:2024 Issue:8 Volume:5 Page:763-775
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Zaykov Alexander N.¹^ORCID,Gelfanov Vasily M.¹^ORCID,Tagmose Tina M.²^ORCID,Demozay Damien²,Manfè Valentina²,Rohlfs Rebecca¹,Rivir Marita³^ORCID,Perez-Tilve Diego³^ORCID,Finan Brian¹,DiMarchi Richard D.¹⁴^ORCID

Affiliation:

1. Novo Nordisk Research Center Indianapolis, Indianapolis, IN 46241, USA

2. Novo Nordisk, Global Research Technologies, DK-2760 Maaloev, Denmark

3. Department of Pharmacology and Systems Physiology, University of Cincinnati-College of Medicine, Cincinnati, OH 45267, USA

4. Department of Chemistry, Indiana University, Bloomington, IN 47405, USA

Abstract

Pharmacokinetic properties of a peptide hormone are extended via the combination of fatty acid acylation and Fc-conjugation, as shown with double protracted insulin analogs. This approach may be expanded to other peptide- and protein-based therapies.

Funder

Novo Nordisk

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00078A

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