Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells

Author:

Harizaj Aranit12345ORCID,Van Hauwermeiren Filip67859,Stremersch Stephan12345,De Rycke Riet10311512,De Keersmaecker Herlinde12345,Brans Toon12345,Fraire Juan C.12345,Grauwen Karolien6785,De Smedt Stefaan C.12345,Lentacker Ine12345,Lamkanfi Mohamed67859,Braeckmans Kevin12345ORCID

Affiliation:

1. Laboratory of General Biochemistry and Physical Pharmacy

2. Faculty of Pharmaceutical Science

3. Ghent University

4. 9000 Ghent

5. Belgium

6. Janssen Immunosciences

7. Pharmaceutical Companies of Johnson & Johnson

8. Beerse

9. Department of Internal Medicine and Pediatrics

10. Department of Biomedical Molecular Biology

11. Ghent

12. VIB Center for Inflammation Research

Abstract

Laser-induced nanoparticle-sensitized photoporation of hard-to-transfect primary macrophages for the ex vivo delivery of inflammasome inducing toxins.

Funder

Fonds Wetenschappelijk Onderzoek

Agentschap Innoveren en Ondernemen

H2020 European Research Council

Bijzonder Onderzoeksfonds

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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