A highly sensitive and selective fluoride sensor based on a riboswitch-regulated transcription coupled with CRISPR-Cas13a tandem reaction-Reference-Cited by-同舟云学术

A highly sensitive and selective fluoride sensor based on a riboswitch-regulated transcription coupled with CRISPR-Cas13a tandem reaction

Published:2021 Issue:35 Volume:12 Page:11740-11747
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ma Yuan¹²^ORCID,Mou Quanbing¹,Yan Peng¹³^ORCID,Yang Zhenglin⁴,Xiong Ying¹,Yan Deyue²^ORCID,Zhang Chuan²^ORCID,Zhu Xinyuan²^ORCID,Lu Yi¹⁴^ORCID

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

2. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

3. Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, PR China

4. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

Abstract

A fluoride sensor based on riboswitch-regulated transcription coupled with Cas13a sensor can detect fluoride in water with a portable fluorometer. This sensor expands nuclei acid sensors to an anion, with high sensitivity and selectivity against other common anions.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03508H

Reference79 articles.

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